HGF Aanbevolen eiwit

HGF is a mesenchymally derived potent mitogen for mature parenchymal hepatocyte cells and acts as a growth factor for a broad spectrum of tissues and cell types. HGF signals through a transmembrane tyrosine kinase receptor known as MET. Activities of HGF include induction of cell proliferation, motility, morphogenesis, inhibition of cell growth, and enhancement of neuron survival. HGF is a crucial mitogen for liver regeneration processes, especially after partial hepatectomy and other liver injuries. Human and murine HGF are cross-reactive. Murine HGF is expressed as a linear 728 amino acid polypeptide precursor glycoprotein. Proteolytic processing of this precursor generates the biologically active form of HGF, which consists of two polypeptide chains (α -chain and β -chain) held by a single disulfide bond resulting in formation of a biologically active heterodimer. The α -chain consists of 463 amino acid residues and four kringle domains. The β -chain consists of 233 amino acid residues.*Manufactured using (BTI-Tn-5B1-4) cells under license from the Boyce Thompson Institute for Plant Research, Inc.

15234

Q08048

NP_001276387.1

Recombinant Proteins

(BTI-Tn-5B1-4) High-5 Insect cells

Greater than 95% by SDS-PAGE gel and HPLC analyses.

Room Temp

The lyophilized HGF recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted HGF stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing HGF recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

Hepatocyte growth factor

Mus musculus

SF, NK1, NK2, HGF/SF, SF/HGF, C230052L06Rik, Hepatocyte growth factor, Hepatopoietin-A, SF

Murine

575501559

Lyophilized