HGS101

HGS101 is a fully human CCR5 monoclonal antibody with high affinity to CCR5. HGS101 binds to the 2nd extracellular loop (ECL-2) and acts as a signal antagonist. HGS101 restores Maraviroc inhibition of Maraviroc-resistant HIV-1 infection of PBMCs. HGS101 shows anti-HIV activity by inhibiting CCR5 signaling in simian immunodeficiency virus-uninfected RMs models[1][2].

12352203

CCR; HIV

Anti-infection; GPCR/G Protein; Immunology/Inflammation

COVID-19-anti-virus

Infection

[1]Latinovic O, et al. CCR5 antibodies HGS004 and HGS101 preferentially inhibit drug-bound CCR5 infection and restore drug sensitivity of Maraviroc-resistant HIV-1 in primary cells. Virology. 2011 Mar 1;411 (1) :32-40.|[2]aaffe JE, et al. CCR5 blockade is well tolerated and induces changes in the tissue distribution of CCR5+ and CD25+ T cells in healthy, SIV-uninfected rhesus macaques. J Med Primatol. 2012 Feb;41 (1) :24-42.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-P991541/

Inhibitory Antibodies

No Development Reported