HHIP (NM 022475) Humaan Recombinant eiwit

This gene encodes a member of the hedgehog-interacting protein (HHIP) family. The hedgehog (HH) proteins are evolutionarily conserved protein, which are important morphogens for a wide range of developmental processes, including anteroposterior patterns of limbs and regulation of left-right asymmetry in embryonic development. Multiple cell-surface receptors are responsible for transducing and/or regulating HH signals. The HHIP encoded by this gene is a highly conserved, vertebrate-specific inhibitor of HH signaling. It interacts with all three HH family members, SHH, IHH and DHH. Two single nucleotide polymorphisms (SNPs) near this gene are significantly associated with risk of chronic obstructive pulmonary disease (COPD) . A single nucleotide polymorphism in this gene is also strongly associated with human height.[provided by RefSeq, Feb 2011]

Purified recombinant protein of Human hedgehog interacting protein (HHIP), His214-Arg671, with N-terminal His tag, expressed in E. coli, 50ug

HIP

64399

Q96QV1

NM_022475

4q31.21

E. coli

N-His

Basal cell carcinoma, Hedgehog signaling pathway, Pathways in cancer

Basal cell carcinoma, Hedgehog signaling pathway, Pathways in cancer

>50 ug/mL as determined by microplate BCA method

> 80% as determined by SDS-PAGE and Coomassie blue staining

Liquid

50mM Tris, 8M Urea, pH8.0

Secreted Protein

51.1 kDa

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

HHIP

Human

NP_071920

https://www.ncbi.nlm.nih.gov/gene/64399

https://www.uniprot.org/uniprot/Q96QV1

https://www.ncbi.nlm.nih.gov/nuccore/NM_022475

https://www.ncbi.nlm.nih.gov/nuccore/NP_071920