Hibariminine C

Hibarimicin C is a tyrosine kinase inhibitor. Hibarimicin C selectively inhibits the activity of src tyrosine kinase without affecting protein kinase A and C. Hibarimicin C also has moderate anti-Gram-positive bacteria activity with a MIC of 0.8-12.56 μg/mL[1].

208588-83-4

12352211

Bacterial; Src

Anti-infection; Protein Tyrosine Kinase/RTK

COVID-19-immunoregulation

Cancer; Infection

CCCC12C3(C(C(C(C2O[C@@H]4O[C@@H]([C@H](CC4)O[C@@H]5O[C@@H]([C@H](CC5)O)C)C)O)O[C@H]6C[C@H]([C@H]([C@@H](O6)C)O)O)([H])C(C7=C(O)C(C(C(OC)=C(C8=C(C(OC)=C9C(C(O)=C%10C(CC%11([H])C(C%10=O)(C(O)(C(C(C%11O[C@H]%12C[C@H]([C@H]([C@@H](O%12)C)O)O)O)O[C@@H]%13O[C@@H]([C@H](CC%13)O[C@@H]%14O[C@H]([C@@](O)(CC%14)C(C)=O)C)C)CCC)O)=C9)=C8O)OC)C%15=O)=O)=C%15C(O)=C7C3=O)([H])O1)O

C83H110O36

1683.74

[1]Sung Ig Cho, et al. Effects of hibarimicins and hibarimicin-related compounds produced by Microbispora on v-Src kinase activity and growth and differentiation of human myeloid leukemia HL-60 cells. J Antibiot (Tokyo) . 2002 Mar;55 (3) :270-8.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-N14273/

Natural Products

No Development Reported