HIF1A Antilichaam

This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

3091

Q16665

Human, Mouse, Rat

Recombinant fusion protein containing a sequence corresponding to amino acids 70-260 of human HIF1A (NP_851397.1) .

Unconjugated

Primary Antibodies

Autophagy, Cancer, Cell Cycle, Signal Transduction, Transcription

Affinity purification

HepG2

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 110kDa

IgG

WB: 1:500 - 1:2000

HIF1A

HT-1080

A-549

Mouse kidney

Mouse skin

Rat kidney

Hypoxia-inducible factor 1-alpha

Homo sapiens

Hypoxia-inducible factor 1-alpha, HIF-1-alpha, HIF1-alpha, ARNT-interacting protein, Basic-helix-loop-helix-PAS protein MOP1, Class E basic helix-loop-helix protein 78, bHLHe78, Member of PAS protein 1, PAS domain-containing protein 8, HIF1A, BHLHE78, MOP1, PASD8

WB

Liquid