Himachalol

Himachalol, a sesquiterpene, is an orally active antispasmodic and anticancer constituent found in the wood of Cedrus deodara. Himachalol has anti-proliferative activity against the melanoma cells, and induces apoptosis (decreases Bcl-2 level and increases Bax level) . Himachalol has systemic hypotension and peripheral vasodilation effect. Himachalol inhibits Carbachol-induced spasm of the intestine. The LD50 of Himachalol in mice is 265 mg/kg (p.o.) and 247 mg/kg (i.p.) [1][2].

1891-45-8

12352211

Apoptosis; Bcl-2 Family

Apoptosis

C[C@@]1([C@@]2([H])[C@](C(C)(CCC1)C)([H])C=C(CC2)C)O

C15H26O

222.37

[1]Shebaby W, et al. Himachalol induces apoptosis in B16-F10 murine melanoma cells and protects against skin carcinogenesis. J Ethnopharmacol. 2020 May 10;253:112545. |[2]Kar K, et al. Spasmolytic constituents of Cedrus deodara (Roxb.) Loud: pharmacological evaluation of himachalol. J Pharm Sci. 1975 Feb;64 (2) :258-262.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-N15424/

Natural Products

No Development Reported