HIPPI (IFT57) Mouse Monoclonal Antibody [Kloon ID: LBI4F6]

Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity) . Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3'present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear

Carrier-free (BSA/glycerol-free) IFT57 mouse monoclonal antibody, clone LBI4F6

ESRRBL1; HIPPI; MHS4R2

Homo sapiens intraflagellar transport 57 (IFT57), mRNA.

55081

Q9NWB7

Unconjugated

Huntington's disease

Huntington's disease

WB 1:2000, IHC 1:50, IF 1:100

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Druggable Genome

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

IFT57

https://www.ncbi.nlm.nih.gov/gene/?term=55081

https://www.uniprot.org/uniprot/Q9NWB7