HIV-2 (subtype A, isolaat ROD) Proteïne Vpx (His)
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host VPRPB/DCAF-1. This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1. In turn, SAMHD1 depletion allows viral replication in host myeloid cells by preventing SAMHD1-mediated hydrolysis of intracellular dNTPs necessary for reverse transcription.
Ice Packs
-20°C
Beschrijving
HIV-2 (subtype A, isolaat ROD) Proteïne Vpx (His) Beschikbaar in 5 µg. Bestel eenvoudig online met snelle levering.
Specificaties
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