HL2-m5

HL2-m5 is the inhibitor for the interaction between sonic hedgehog/patched (Shh/PTCH1) with Kd of 170 nM for Shh. HL2-m5 inhibits activation of Hedgehog signaling pathway and transcription of Gli-controlled gene with an IC50 of 230 nM[1].

2130846-15-8

12352209

Hedgehog

Stem Cell/Wnt

Cancer

98.06

DMSO : 50 mg/mL (ultrasonic)

OC(C[C@@H](C(N)=O)NC([C@H]([C@H](O)C)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC1=O)CCC(O)=O)=O)C)=O)CCSC)=O)CC(O)=O)=O)CCSC)=O)CSCCOC2=CC=C(C=C2)C[C@@H]1NC([C@@H](NC([C@H](CO)NC([C@H](CC(C)C)NC([C@H]([C@H](O)C)NC(C)=O)=O)=O)=O)CC3=CNC4=CC=CC=C34)=O)=O)=O)=O

C70H101N15O24S3

1632.83

[1]Owens AE, et al., Design and Evolution of a Macrocyclic Peptide Inhibitor of the Sonic Hedgehog/Patched Interaction. J Am Chem Soc. 2017 Sep 13;139 (36) :12559-12568.

Blue Ice

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

http://file.medchemexpress.com/batch_PDF/HY-P10875/HL2-m5-SDS-MedChemExpress.pdf

Peptides

No Development Reported