HLA-DOB Antilichaam - N-terminaal gebied: Biotine (ARP61712 P050-Biotine)

Major histocompatibility complex, class II, DO beta

DOB, HLA_DOB

3112

Q5QNS2

NP_002111

Human, Cow, Dog, Horse, Pig, Rabbit, Sheep

The immunogen is a synthetic peptide directed towards the N-terminal region of Human HLA-DOB

HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages) . The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.

HLA-DMB; CD82; CD63

Biotin

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Cow: 79%; Dog: 93%; Horse: 93%; Human: 100%; Pig: 93%; Rabbit: 86%; Sheep: 86%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

30kDa

Wet Ice

273

HLA-DOB

HLA-DOB

Rabbit

MHC class II antigen EMBL AAV97948.1

NM_002120

LTRLDSSMTQGTDSPEDFVIQAKADCYFTNGTEKVQFVVRFIFNLEEYVR