HLA-DPB1 Antilichaam

HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages) . The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.

3115

P04440

Human, Mouse, Rat

Recombinant fusion protein containing a sequence corresponding to amino acids 30-225 of human HLA-DPB1 (NP_002112.3) .

Unconjugated

Primary Antibodies

Immunology

Affinity purification

U-937

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 27-29kDa

IgG

HLA-DPB1

THP-1

Mouse spleen

Mouse thymus

HLA class II histocompatibility antigen, DP beta 1 chain

Homo sapiens

HLA class II histocompatibility antigen, DP beta 1 chain, HLA class II histocompatibility antigen, DP (W4) beta chain, MHC class II antigen DPB1, HLA-DPB1, HLA-DP1B

WB, IHC

Liquid