HLA-DRB3 Antilichaam

HLA-DRB3 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages) . The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB3 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.

3125

P79483

Human, Mouse, Rat

Recombinant fusion protein containing a sequence corresponding to amino acids 30-227 of human HLA-DRB3 (NP_072049.2) .

Unconjugated

Primary Antibodies

Immunology

Affinity purification

Raji

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 30kDa

IgG

WB: 1:500 - 1:2000

HLA-DRB3

Mouse liver

Rat liver

Major histocompatibility complex, class II, DR beta 3

Homo sapiens

DRB3, HLA-DPB1, HLA-DR1B, HLA-DR3B, major histocompatibility complex, class II, DR beta 3, HLA DRB3, HLA class II histocompatibility antigen, DR beta 3 chain, MHC class II HLA-DR beta 3 chain, MHC class II antigen DR beta 3 chain, MHC class II antigen DRB3, human leucocyte antigen DRB3

WB

Liquid