HMGA2 Antilichaam - N-terminaal gebied: Biotine (ARP38356 T100-Biotine)

High mobility group AT-hook 2

BABL, LIPO, SRS5, HMGIC, HMGI-C, STQTL9

8091

P52926

NP_003474

Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Rabbit, Yeast, Zebrafish

The immunogen is a synthetic peptide directed towards the N terminal region of human HMGA2

HMGA2 belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. It may be play a role in adipogenesis, mesenchymal differentiation and diet-induced obesity.This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

PSIP1; SYNCRIP; PTBP1; PCBP2; PA2G4; NPM1; XRCC6; APEX1; HDGF; UBC; PRKCA; SMAD9; SMAD5; SMAD1; PRMT6; RB1; PIAS3; SMAD3; RELA; NFKB1; CDK1; CSNK2A2; CSNK2A1

Biotin

Polyclonal Antibody

WB

HMGA2 is supported by BioGPS gene expression data to be expressed in HEK293T

0.5 mg/ml

Cow: 100%; Dog: 100%; Goat: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Yeast: 92%; Zebrafish: 100%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

12kDa

Kubo, T., (2006) Biochem. Biophys. Res. Commun. 340 (2), 476-481

Wet Ice

109

HMGA2

HMGA2

Rabbit

High mobility group protein HMGI-C

NM_003483

PSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSP