HMGB1 Antilichaam

The high-mobility group box 1 (HMGB1) protein was originally identified as a highly conserved nuclear DNA-binding protein that participates in DNA replication, repair and transcriptional regulation of gene expression (1,2) . However, HMGB1 has more recently emerged as an extracellularly released mediator of inflammation and repair responses in lipopolysaccharide (LPS) -induced endotoxemia and sepsis (3) . HMGB1 has also been suggested to induce secretion of pro-inflammatory cytokines and chemokines by inducing NF-kB signaling downstream of Toll-like receptor (TLR) 2 and TLR4 activation (4) .

3146

P09429

NP_002119

Human, Mouse, Rat

7715

Unconjugated

Primary Antibodies

KO Validation (Figure 1) : Anti-HMGB1 antibodies (7715) specificity was further verified by HMGB1 specific knockout cell lysate. HMGB1 signal was detected in wild type cells, but not in the HMGB1 knockout cells. KO Validation7715)

Innate Immunity

HMGB1 antibody is affinity chromatography purified via peptide column.

Cat. No. 1303 - Human Brain Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Chicken: (100%), Pig: (100%)

HMGB1 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

HMGB1 antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.

IgG

HMGB1 antibody is human, mouse and rat reactive.

Human HMGB1 has only 1 isoform (215aa, 25kD) . Mouse HMGB1 has only 1 isoform (215aa, 25kD) . Rat HMGB1 has only 1 isoform (215aa, 25kD) . This antibody detects HMGB1 of human, mouse and rat.

HMGB1

Cat. No. 10-101 - Human Lung Tissue Slide

High mobility group box 1

Homo sapiens

Smerdon MJ and Isenberg I. Interactions between the subfractions of calf thymus H1 and nonhistone chromosomal proteins HMG1 and HMG2. Biochemistry 1976; 15:4242-7.

Stros. Biocim. Biophys. Acta. 2010; 1799:101-113.

Wang et al. Science 1999; 285:248-51.

Van Zoelenet al. Shock 2009; 31:280-4.

Wei etal. Cell 2021; 184:76-91.

HMGB1 Antibody: HMG1, HMG3, SBP-1, HMG1, High mobility group protein B1, High mobility group protein 1, HMG-1

ELISA, WB, IHC-P, IF

4504425

Liquid