HMGCR Antilichaam

HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

3156

P04035

Human, Mouse, Rat

Recombinant fusion protein containing a sequence corresponding to amino acids 629-888 of human HMGCR (NP_000850.1) .

Unconjugated

Primary Antibodies

Cancer, Signal Transduction

Affinity purification

HepG2

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 110kDa

IgG

WB: 1:1000 - 1:4000IHC: 1:50 - 1:100

HMGCR

HeLa

SH-SY5Y

BT-474

Mouse spleen

Rat liver

3-hydroxy-3-methylglutaryl-CoA reductase

Homo sapiens

HMG-CoA reductase, hydroxymethylglutaryl-CoA reductase, 3-hydroxy-3-methylglutaryl CoA reductase (NADPH), LDLCQ3, 3-hydroxy-3-methylglutaryl-Coenzyme A reductase, HMGCR

WB, IHC

Liquid