HMGCR Antilichaam - C-terminalgebied: FITC (ARP44343_P050-FITC)

3-hydroxy-3-methylglutaryl-CoA reductase

LDLCQ3

3156

P04035

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Yeast

The immunogen is a synthetic peptide directed towards the C-terminal region of Human HMGCR

HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

UBC; INSIG1; AMFR; INSIG2; AUP1; DCUN1D1; ERLIN2; RNF139; VCP; STARD13; ARHGAP1; PRKACA; HMGCR

FITC: Fluorescein Isothiocyanate

Polyclonal Antibody

WB

Affinity purified

0.5 mg/ml

Cow: 93%; Dog: 100%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 93%; Rat: 100%; Yeast: 100%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

97kDa

Wet Ice

888

HMGCR

HMGCR

Rabbit

3-hydroxy-3-methylglutaryl-coenzyme A reductase

PSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLARIVCGTVM