HMGCR (NM 000859) Humaan Recombinant Proteïne

HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

Purified recombinant protein of Human 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), transcript variant 1, Gln341-Glu620, with N-terminal His tag, expressed in E. coli, 50ug

LDLCQ3

3156

P04035, A0A024RAP2

NM_000859

5q13.3

E. coli

N-His

Metabolic pathways, Terpenoid backbone biosynthesis

Metabolic pathways, Terpenoid backbone biosynthesis

>50 ug/mL as determined by microplate BCA method

> 80% as determined by SDS-PAGE and Coomassie blue staining

Liquid

25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1% Sarkosyl.

Druggable Genome, Transmembrane

30.7 kDa

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

HMGCR

Human

NP_000850

https://www.ncbi.nlm.nih.gov/gene/3156

https://www.uniprot.org/uniprot/P04035

https://www.ncbi.nlm.nih.gov/nuccore/NM_000859

https://www.ncbi.nlm.nih.gov/nuccore/NP_000850