HMGN1 Antilichaam - middengebied HRP (ARP32627 P050-HRP)

High mobility group nucleosome binding domain 1

HMG14

3150

P05114

NP_004956

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit

The immunogen is a synthetic peptide directed towards the middle region of human HMGN1

Chromosomal protein HMG14 (HMGN1) and its close analog HMG17 (MIM 163910) bind to the inner side of the nucleosomal DNA, potentially altering the interaction between the DNA and the histone octamer. The 2 proteins may be involved in the process that maintains transcribable genes in a unique chromatin conformation. Their ubiquitous distribution and relative abundance, as well as the high evolutionary conservation of the DNA-binding domain of the HMG14 family of proteins, suggest that they may be involved in an important cellular function.Chromosomal protein HMG14 and its close analog HMG17 (MIM 163910) bind to the inner side of the nucleosomal DNA, potentially altering the interaction between the DNA and the histone octamer. The 2 proteins may be involved in the process that maintains transcribable genes in a unique chromatin conformation. Their ubiquitous distribution and relative abundance, as well as the high evolutionary conservation of the DNA-binding domain of the HMG14 family of proteins, suggest that they may be involved in an important cellular function.[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

UBC; RPS6KA3; PRKCA; PRKACG; SLC38A3; PPP1CC; LIG4; PPIP5K1; TERF2; SPP1; POLR2A; ERCC8; HDGF; EP300; BTG2; ERCC6; NFE2; RPS6KA5; RPS6KA4; PRKACA; YWHAZ; HMGN1; HMGN2; IRF2

HRP: Horseradish Peroxidase

Polyclonal Antibody

IHC, WB

Affinity Purified

HMGN1 is strongly supported by BioGPS gene expression data to be expressed in 721_B

0.5 mg/ml

Cow: 100%; Dog: 100%; Guinea Pig: 79%; Horse: 100%; Human: 100%; Mouse: 77%; Pig: 86%; Rabbit: 93%; Rat: 100%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

11kDa

Zhu, N. (2007) Mol. Cell. Biol. 27 (24), 8859-8873

Wet Ice

100

HMGN1

HMGN1

Rabbit

Non-histone chromosomal protein HMG-14

NM_004965

PKKAAAKDKSSDKKVQTKGKRGAKGKQAEVANQETKEDLPAENGETKTEE