HNRNPR Antibody - N-terminal regio : HRP (ARP40605 P050-HRP)

Heterogeneous nuclear ribonucleoprotein R

HNRPR, hnRNP-R

10236

O43390

NP_005817

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

The immunogen is a synthetic peptide directed towards the N terminal region of human HNRNPR

HNRNPR belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs) . The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA) . These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein has three repeats of quasi-RRM domains that bind to RNAs and also contains a nuclear localization motif. Multiple alternatively spliced transcript variants have been found for this gene. This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs) . The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA) . These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs and also contains a nuclear localization motif. Multiple alternatively spliced transcript variants have been found for this gene.

PRMT1; KHDRBS2; CEP250; SUMO2; IVNS1ABP; STAU1; UBC; MDM2; WWOX; ZBTB1; RPA3; RPA2; RPA1; RNF2; EED; rev; PPP4R1; MTA2; CCDC6; EHBP1L1; RABEP2; BRCC3; SMEK1; LSM8; LARP7; GAPVD1; CD2AP; WDHD1; SF3A1; TRIM28; HDAC1; NR3C1; POLR2C; POLR2A; MAP4; PARK2; SRPK

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

Affinity Purified

HNRNPR is strongly supported by BioGPS gene expression data to be expressed in 721_B

0.5 mg/ml

Cow: 93%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

71kDa

Szafranski, K., Genome Biol. 8 (8), R154 (2007)

Wet Ice

633

HNRNPR

HNRNPR

Rabbit

Heterogeneous nuclear ribonucleoprotein R

NM_005826

ANQVNGNAVQLKEEEEPMDTSSVTHTEHYKTLIEAGLPQKVAERLDEIFQ