HOPX-antilichaam

HOPX is a small homeodomain protein that lacks normally conserved residues required for DNA binding (1) . It is thought to act downstream of NKX2-5 and modulates serum response factor (SRF) -dependent cardiac-specific gene expression and cardiac development (1) . HOPX also acts a tumor suppressor gene in multiple tumors and cancer cell lines (2,3) . HOPX has been reported to regulate the proliferation/differentiation homeostasis in different cell types, including keratinocytes (4) .

84525

Q9BPY8

NP_001138932

Human

Unconjugated

Primary Antibodies

Cancer, Stem Cell

HOPX antibody is affinity chromatography purified via peptide column.

Cat. No. 1303 - Human Brain Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Rat: (88%), Mouse: (88%), Bovine: (88%), Pig: (81%), Chicken: (81%)

HOPX antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

HOPX antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

HOPX antibody is human specific. At least three isoforms of HOPX are known to exist; this antibody will detect all three isoforms.

HOPX

Cat. No. 10-501 - Human Heart Tissue Slide

HOP homeobox

Homo sapiens

Chen F, Kook H, Milewski R, et al. Hop is an unusual homeobox gene that modulates cardiac development. Cell 2002; 110:713-23.

Asanoma K, Matsuda T, Kondo H, et al. NECC1, a candidate choriocarcinoma suppressor gene that encodes a homeodomain consensus motif. Genomics 2003; 81:15-25.

Katoh H, Yamashita K, Waraya M, et al. Epigenetic silencing of HOPX promotes cancer progression in colorectal cancer. Neoplasia 2012; 14:559-71.

Obarzanek-Fojt M, Favre B, Kypriotou M, et al. Homeodomain-only protein HOP is a novel modulator of late differentiation in keratinocytes. Eur. J. Cell Biol. 2011; 90:279-90.

HOP homeobox, homeodomain-only protein, CAMEO, HOD, HOP, LAGY, NECC1, OB1, SMAP31, TOTO

ELISA, WB, IHC-P, IF

224451025

Liquid