HR Antilichaam

This gene encodes a protein that is involved in hair growth. This protein functions as a transcriptional corepressor of multiple nuclear receptors, including thyroid hormone receptor, the retinoic acid receptor-related orphan receptors and the vitamin D receptors, and it interacts with histone deacetylases. The translation of this protein is modulated by a regulatory open reading frame (ORF) that exists upstream of the primary ORF. Mutations in this upstream ORF cause Marie Unna hereditary hypotrichosis (MUHH), an autosomal dominant form of genetic hair loss. Mutations in this gene also cause autosomal recessive congenital alopecia and atrichia with papular lesions, other diseases resulting in hair loss. Two transcript variants encoding different isoforms have been found for this gene.

55806

O43593

Human, Mouse, Rat

Recombinant fusion protein containing a sequence corresponding to amino acids 200-480 of human HR (NP_005135.2) .

Unconjugated

Primary Antibodies

Transcription

Affinity purification

U-251MG

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 120kDa

IgG

WB: 1:500 - 1:1000

HR

Mouse brain

Rat brain

Hair growth associated

Homo sapiens

HR, ALUNC, AU, HSA277165, MUHH, MUHH1

WB

Liquid