HSD17B13 Antilichaam / 17-beta-HSD 13

Hydroxysteroid 17-beta dehydrogenase 13 (HSD17B13) is an engyme in the liver that is associated with lipid droplets. It is encoded by the HSD17B13 gene in humans. HSD17B13 levels increase in patients with non-alcoholic fatty liver disease (NAFLD) and can enhance lipogenesis. However, some studies have shown that loss-of-function variants in HSD17B13 may protect against the progression of NAFLD to non-alcoholic steatohepatitis, fibrosis, and hepatocellular carcinoma.

Immunohistochemistry (FFPE) : 1-2 µg/mL

Q7Z5P4

Human

A portion of amino acids 1-200 of the human protein was used as the immunogen for the HSD17B13 antibody.

HSD17B13/13106

IHC-P

Protein G affinity

Purified

This HSD17B13 antibody is available for research use only.

Aliquot the HSD17B13 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide

Optimal dilution of the HSD17B13 antibody should be determined by the researcher.

Cytoplasm

IHC staining of FFPE human hepatocellular carcinoma tissue with HSD17B13 antibody (clone HSD17B13/13106) . Inset: PBS used in place of primary Ab (secondary Ab negative control) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.