HSET1 Antilichaam / SET1 / SETD1A

Histone-lysine N-methyltransferase SETD1A is an enzyme that in humans is encoded by the SETD1A gene. It is mapped to 16p11.2. The protein encoded by this gene is a component of a histone methyltransferase (HMT) complex that produces mono-, di-, and trimethylated histone H3 at Lys4. Trimethylation of histone H3 at lysine 4 (H3K4me3) is a chromatin modification known to generally mark the transcription start sites of active genes. The protein contains SET domains, a RNA recognition motif domain and is a member of the class V-like SAM-binding methyltransferase superfamily.

Western blot: 0.5-1 µg/mL, Direct ELISA: 0.1-0.5 µg/mL

O15047

Human

Recombinant human protein (amino acids D8-K153) was used as the immunogen for the hSET1 antibody.

WB, Direct ELISA

Affinity purified

Antigen affinity purified

Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide

This hSET1 antibody is available for research use only.

After reconstitution, the hSET1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

0.5 mg/mL if reconstituted with 0.2ml sterile DI water

Optimal dilution of the hSET1 antibody should be determined by the researcher.

Nuclear

Western blot testing of human 1) SW620 and 2) U-87 MG lysate with hSET1 antibody. Predicted molecular weight ~186 kDa.