Humaan Aldo-keto reductase 7A3/AKR7A3-antilichaam

Aldo-keto reductase family 7, member A 3 (AKR7A3) is a member of the aldo/keto reductase superfamily involved in the detoxification and metabolism of a variety of exogenous aldehydes and ketones. The activity of AKR7A3 may detoxify the aflatoxin B1 (AFB1) dialdehyde, which reacts with proteins, and thereby inhibitis AFB1 induced toxicity. AKR7A3 is expressed in kidney, colon, pancreas, endometrium and adenocarcinoma.

Aldo-keto reductase family 7 member A 3, Aflatoxin B1 aldehyde reductase member 3, AFB1 aldehyde reductase 2 (AFAR2), AFB1 AR 2, Aflatoxin aldehyde reductase, Aflatoxin B1 aldehyde reductase 2

Human

Human

Recombinant human AKR7A3 (1-331aa) purified from E. coli

AT2E11

Unconjugated

ELISA, WB

By protein-G affinity chromatography

1 mg/mL (determined by BCA assay)

AKR7A3, ATGA0216-10 µg, ATGA0216-20 µg, ATGA0216-50 µg, ATGA0216-100 µg, ATGA0216-250 µg, ATGA0216-500 µg, ATGA0216-1 mg, ATGA0216-10, ATGA0216-20, ATGA0216-50, ATGA0216-100, ATGA0216-250, ATGA0216-500, ATGA0216-1

Chem Res Toxicol 2008, 21:1134-1142.; ; J. Biol. Chem. 267 (34) : 24841-7. ; ; Chem Res Toxicol 2008, 21:1134-1142.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol

The antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results.

Signal Transduction

AAH25709

O95154

The cell lysates (5ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human AKR7A3 antibody (1:3000) . Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. ; ; Lane 1.: 293T cell lysate ; ; Lane 2.: AKR7A3 Transfected 293T cell lysate