Humaan Calsequestrin 2/CASQ2 antilichaam

CASQ2 (Calsequestrin 2) protein responsible for holding Calcium together with other two proteins junction and triadin at the sarcoplasmic reticulum renders the hear vulnerable to severe cardiac arrhythmias, known as CPVT (catecholaminergic polymorphic ventricular tachycardia), during physical exercise.

Cardiac muscle calsequestrin 2, PDIB2

Human

Human

Recombinant human CASQ2 (20-399aa) purified from E. coli

AT4E10

Unconjugated

ELISA, WB, ICC/IF

By protein-G affinity chromatography

1 mg/mL (determined by BCA assay)

CASQ2, ATGA0202-10 µg, ATGA0202-20 µg, ATGA0202-50 µg, ATGA0202-100 µg, ATGA0202-250 µg, ATGA0202-500 µg, ATGA0202-1 mg, ATGA0202-10, ATGA0202-20, ATGA0202-50, ATGA0202-100, ATGA0202-250, ATGA0202-500, ATGA0202-1

Eckstein, A.K., et al. (2006) J. Clin. Endo. and Meta. 91: 3464-3470.; ; Paschke, R., et al (1995) Clin. Endo. 42: 565-569.; ; Bahn, R.S. (2003) J. Clin. Endo. and Meta. 88: 1939-1946.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol

The antibody has been tested by ELISA, Western blot and ICC/IF analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results.

Cardiovascular

NP_001223

O14958

The tissue lysates of Mouse muscle (35ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human CASQ2 (1:1000) . Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.

ICC/IF analysis of CASQ2 in HeLa cells. The cell was stained with ATGA0202 (1:100) . The secondary antibody (green) was used Alexa Fluor 488. DAPI was stained the cell nucleus (blue) .