Humaan COMMD7 antilichaam

COMMD family members are a group of evolutionary conserved proteins that share a common COMM domain at the extreme C-terminus, which provides an interface for protein-protein interactions. COMMD proteins may also play a role in the function of epithelial sodium channels, cell proliferation, and copper homeostasis and in the regulation of the ubiquitin pathway. With highest expression in lung, COMMD7 (COMM domain-containing protein 7) is a 200 amino acid protein that binds COMMD1 via its COMM domain.

COMM domain-containing protein 1, C2orf5, MuRR1, COMM domain-containing protein 1, COMMD-1, COMMD 1, COMM, MuRR 1, MuRR-1

Human

Human

Recombinant human COMMD7 (1-200aa) purified from E. coli

AT49B5

Unconjugated

ELISA, WB, ICC/IF

By protein-A affinity chromatography

1 mg/mL (determined by BCA assay)

COMMD7, ATGA0354-10 µg, ATGA0354-20 µg, ATGA0354-50 µg, ATGA0354-100 µg, ATGA0354-250 µg, ATGA0354-500 µg, ATGA0354-1 mg, ATGA0354-10, ATGA0354-20, ATGA0354-50, ATGA0354-100, ATGA0354-250, ATGA0354-500, ATGA0354-1

Burstein E., et al. (2005) J Biol Chem. 280 (23) : 22222-22232.; ; De Bie P., et al. (2006) Biochem J. 398 (1) : 63-71.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol

The antibody has been tested by ELISA, Western blot and ICC/IF analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results.

Signal Transduction

NP_444269

Q86VX2

The cell lysates (40ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human COMMD7 antibody (1:1000) . Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.; ; Lane 1.: A549 cell lysate; ; Lane 2.: HepG2 cell lysate

ICC/IF analysis of COMMD7 in A549 cells line, stained with monoclonal anti-human COMMD7 antibody (1:100) with goat anti-mouse IgG-Alexa fluor 488 conjugate (Green) .