Humaan FBP2-antilichaam

FBP2 (Fructose-1, 6-bisphosphatase isozyme 2) is a 339 amino acid protein. FBP2 belongs to the FBPase class 1 family. The hydrolysis of fructose-1, 6-bisphosphate to fructose-6-phosphate is a key reaction of carbohydrate metabolism. The enzyme that catalyzes this reaction appears to be present in all forms of living organisms. FBPase is encoded by two genes, FBP1 and FBP2, which express the liver and muscle isoforms, respectively. FBPase is regulated by AMP inhibition in most species. Inhibition of FBPase by AMP affects the turnover of bound substrate and not its affinity for substrate.

Fructose-16-bisphosphatase isozyme 2, Fructose-1,6-bisphosphatase isozyme 2

Human

Human

Recombinant human FBP2 (1-339aa) purified from E. coli

AT1E11

Unconjugated

ELISA, WB

By protein-G affinity chromatography

1 mg/mL (determined by BCA assay)

FBP2, ATGA0235-10 µg, ATGA0235-20 µg, ATGA0235-50 µg, ATGA0235-100 µg, ATGA0235-250 µg, ATGA0235-500 µg, ATGA0235-1 mg, ATGA0235-10, ATGA0235-20, ATGA0235-50, ATGA0235-100, ATGA0235-250, ATGA0235-500, ATGA0235-1

Dzugaj, A., et al. (1980) Biochim Biophys Acta 614: 407-412.; ; Marcus, F., et al. (1987) Arch Biol Med Exp 20: 371-378.; ; Matsuura, T., et al. (2002) Mol Genet Metab 76: 207-210.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol

The antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results.

Metabolism

NP_003828

O00757

The cell lysate of mouse muscle (40ug) was resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human FBP2 antibody (1:1000) . Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.