Humaan Laminine 421 Proteïne, premium kwaliteit

Laminin 421, predominantly found in vascular and dynamic tissue niches, plays a critical role in guiding stem cell differentiation towards specific lineages, particularly endothelial and pancreatic cells. Its expression provides key signals that help establish the functional characteristics of these cell types. During the differentiation of pluripotent stem cells (iPSCs/ESCs) into endothelial cells​ (the building blocks of blood vessels), LN421 in the microenvironment promotes the proliferation and assembly of endothelial progenitors, directly supporting vascular tissue formation. Similarly, in the context of pancreatic differentiation, LN421 is a natural component of the pancreatic epithelium basement membrane. Its presence is crucial for the efficient generation of insulin-producing pancreatic beta cells from stem cells, as it interacts with specific integrin receptors to promote the survival and functional maturation of these precious cell types, holding significant promise for diabetes research and cell therapy.

Laminin 421, predominantly found in vascular and dynamic tissue niches, plays a critical role in guiding stem cell differentiation towards specific lineages, particularly endothelial and pancreatic cells. Its expression provides key signals that help establish the functional characteristics of these cell types. During the differentiation of pluripotent stem cells (iPSCs/ESCs) into endothelial cells​ (the building blocks of blood vessels), LN421 in the microenvironment promotes the proliferation and assembly of endothelial progenitors, directly supporting vascular tissue formation. Similarly, in the context of pancreatic differentiation, LN421 is a natural component of the pancreatic epithelium basement membrane. Its presence is crucial for the efficient generation of insulin-producing pancreatic beta cells from stem cells, as it interacts with specific integrin receptors to promote the survival and functional maturation of these precious cell types, holding significant promise for diabetes research and cell therapy.

This protein .

Laminin 421

Unconjugated

-20°C to -70°C for 24 months in lyophilized state; -70°C for 12 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.

0.05 EU per μg

90%

Powder

PBS, pH7.4

Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/support/shipping-and-payments

RT

-20°C

500ug*2

HEK293

Human

Trehalose