Humaan LSM2-antilichaam

LSM2 is a member of the LSm family of RNA-binding proteins. Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner. Component of the cytoplasmic complex which is thought to be involved in mRNA degradation by activating the decapping step. Component of the nuclear LSM2 complex, which is involved in splicing of nuclear mRNAs. LSM2 associates with multiple snRNP complexes containing the U6 snRNA It binds directly to the U6 snRNA and plays a role in the biogenesis and stability of the U6 snRNP and U4/U6 snRNP complexes. It probably also is involved degradation of nuclear pre-mRNA by targeting them for decapping. LSM2 binds specifically to the 3'-terminal U-tract of U6 snRNA. LSM2-LSM8 probably is involved in processing of pre-tRNAs, pre-rRNAs and U3 snoRNA.

U6 snRNA-associated Sm-like protein LSm2, Protein G7b, Small nuclear ribonuclear protein D homolog, snRNP core Sm-like protein Sm-x5, C6orf28, YBL026W

Human

Human

Recombinant human LSm2 (1-95aa) purified from E. coli

1G7

Unconjugated

ELISA, WB

By protein-G affinity chromatography

1 mg/mL (determined by BCA assay)

C6orf28, G7b, LSm2, Protein G7b, Small nuclear ribonuclear protein D homolog, snRNP, snRNP core Sm-like protein Sm-x5, u6 snRNA-associated Sm-like protein LSm2, YBL026W, ATGA0226-10 µg, ATGA0226-20 µg, ATGA0226-50 µg, ATGA0226-100 µg, ATGA0226-250 µg, ATGA0226-500 µg, ATGA0226-1 mg, ATGA0226-010, ATGA0226-020, ATGA0226-050, ATGA0226-100, ATGA0226-250, ATGA0226-500, ATGA0226-01M

Luhtala N, Parker R.Nucleic Acids Res. 2009 Sep 37 (16) :5529-36.; ; Fernandez CF, Pannone BK, Chen X, Fuchs G, Wolin SL .Mol Biol Cell. 2004Jun 15 (6) :2842-52.; ; Achsel T., et al. (1999) EMBO J. 18:5789-5802.;

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol

The antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results.

Epigenomics (Transcription & Translation)

NP_067000

Q9Y333

The cell lysates (20 µg) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human LSm2 antibody (1:1,000) . Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.; ; Lane 1.: MCF7 cell lysate; ; Lane 2.: HeLa cell lysate; ; Lane 3.: 293T cell lysate;