Humaan NKp30/NCR3 antilichaam

NCR3, also known as NKP30, is a natural cytotoxicity receptor (NCR) that may aid NK cells in the lysis of tumor cells. The encoded protein interacts with CD3-zeta (CD247), a T-cell receptor. A single nucleotide polymorphism in the 5' untranslated region of this gene has been associated with mild malaria suceptibility. Three transcript variants encoding different isoforms have been found for this gene.

Natural cytotoxicity triggering receptor 3, 1C7, CD337, LY117, MALS, NKp30

Human

Human

Recombinant human NCR3 (19-138aa) purified from E. coli

AT38D9

Unconjugated

ELISA, WB

By protein-A affinity chromatography

1 mg/mL (determined by BCA assay)

NKp30, NCR3, ATGA0508-10 µg, ATGA0508-20 µg, ATGA0508-50 µg, ATGA0508-100 µg, ATGA0508-250 µg, ATGA0508-500 µg, ATGA0508-1 mg, ATGA0508-10, ATGA0508-20, ATGA0508-50, ATGA0508-100, ATGA0508-250, ATGA0508-500, ATGA0508-1

Venter J.C., et al. (2001) Science. 291:1304-1351.; ; Gerhard D.S., et al. (2004) Genome Res. 14:2121-2127.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol

The antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results.

Immunology

NP_001138939

O14931

The cell lysates (40ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human NCR3 antibody (1:1000) . Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.; ; Lane 1.: THP-1 cell lysate ; ; Lane 2.: Ramos cell lysate ; ; Lane 3.: TF-1 cell lysate