Humaan NKp46/NCR1-antilichaam

A natural cytotoxicity receptor (NCR), Nkp46, is a glycoprotein that has two extracellular Ig-like domains followed by a ~40 residue stalk resion, a type I transmembrane domain, and a short cytoplasmic tail. Nkp46 has been shown to represent a novel Nk cell-specific molecule involved in human Nk cell activation. The natural cytotoxicity receptors (NCRs) are a recently characterized family of Ig-like activation receptors that appearto be major triggering receptors in tumor cell recognition. Nkp46 has been implicated in Nk cell-mediated lysis of several autologous tumor cells and pathogen-infected cell lines.

NKp46 Extracellular Ig-like domain, NK-p46, NK cell-activating receptor, NCR1, NCR, Natural killer cell p46-related protein, Natural cytotoxicity triggering receptor 1 isoform a, Natural cytotoxicity triggering receptor 1, Lymphocyte antigen 94 homolog, Ly96, LY94, hNKp46, CD335 antigen

Human

Human

Recombinant human Nkp46/NCR1 (22-255aa) purified from E. coli.

N1D9

Unconjugated

ELISA, FACS

1 mg/mL (determined by BCA assay)

NKp46 Extracellular Ig-like domain, NKp-46 Extracellular Ig-like domain, NKp46, NK p46, NK-p46, NK cell-activating receptor, NCR-1, NCR 1, NCR1, NCR, Natural killer cell p46-related protein, Natural cytotoxicity triggering receptor 1 isoform a, Natural cytotoxicity triggering receptor 1, Lymphocyte antigen 94 homolog, Ly96, LY94, hNKp46, CD335 antigen, ATGA0526-10 µg, ATGA0526-20 µg, ATGA0526-50 µg, ATGA0526-100 µg, ATGA0526-250 µg, ATGA0526-500 µg, ATGA0526-1 mg, ATGA0526-010, ATGA0526-020, ATGA0526-050, ATGA0526-100, ATGA0526-250, ATGA0526-500, ATGA0526-01M

Sivori, S. et al., (1997) J. Exp. Med. 186:1125-36.; ; Pessino, A. et al., (1998) J. Exp. Med. 188:953-60.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol

The antibody has been tested by ELISA and Flow cytometry to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results.

Immunology

NP_004820

O76036

Flow cytometry analysis of NKp46/NCR1 in PBMC. The cell was stained with ATGA0526 at 2-5ug for 1x10^6cells (red) . A Goat anti mouse IgG (Alexa fluor 488) was used as the secondary antibody. Mouse monoclonal IgG was used as the isotype control (darkgray), cells without incubation with primary and secondary antibody was used as the negative control (light gray) .Flow cytometry analysis of NKp46/NCR1 in HeLa cells. The cell was stained with ATGA0526 at 2-5ug for 1x10^6cells (red) . A Goat anti mouse IgG (Alexafluor 488) was used as the secondary antibody. Mouse monoclonal IgG was used as the isotype control (dark gray), cells without incubation with primary and secondary antibody was used as the negative control (light gray) . {ATGA0526-FC2.jpg}