Humaan NMNAT-1 antilichaam

NMNAT1, also known as NMNAT or PNAT1, is a central enzyme in NAD biosynthesis, catalyzing the condensation of nicotinamide mononucleotide (NMN) or nicotinic acid mononucleotide (NaMN) with the AMP moiety of ATP to form NAD or NaAD. It is widely expressed with high levels in skeletal muscle, heart, liver and kidney. This protein appears to have the ability to protect against axonal degeneration following mechanical or toxic insults.

Nicotinamide nucleotide adenylyltransferase 1, Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1, NMN/NaMN adenylyltransferase 1, Nicotinamide nucleotide adenylyltransferase, Leber's congenital amaurosis 9, LCA9, PNAT1, NMNAT

Human

Human

Recombinant human NMNAT1 (19-609aa) purified from E. coli

AT4G8

Unconjugated

ELISA, WB

By protein-A affinity chromatography

1 mg/mL (determined by BCA assay)

PNAT1, PNAT 1, NMNAT1, NMNAT 1, NMNAT, NMN/NaMN adenylyltransferase1, NMN/NaMN adenylyltransferase 1, Nicotinamide/nicotinic acid mononucleotide adenylyltransferase1, Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1, Nicotinamide nucleotide adenylyltransferase1, Nicotinamide nucleotide adenylyltransferase 1, Nicotinamide nucleotide adenylyltransferase, Leber's congenital amaurosis 9, LCA9, ATGA0516-10 µg, ATGA0516-20 µg, ATGA0516-50 µg, ATGA0516-100 µg, ATGA0516-250 µg, ATGA0516-500 µg, ATGA0516-1 mg, ATGA0516-010, ATGA0516-020, ATGA0516-050, ATGA0516-100, ATGA0516-250, ATGA0516-500, ATGA0516-01M

Emanuelli M. et al. (2001) J Biol Chem. 276 (1) :406-12.; ; Zhou T, ., et al. (2002) J Biol Chem. 277 (15) :13148-54.

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol

The antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results.

Neuroscience

NP_073624

Q9HAN9

The cell lysates were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human NMNAT-1 antibody (1:2000) . Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.; ; Lane 1.: 293T cell lysate (40ug) ; ; Lane 2.: NMNAT1 transfected 293T cell lysate (10 µg)