Humaan oligomerisch a-synucleïne snelle ELISA-test

Alpha synuclein is an abundant 140 amino acid neuronal protein, expressed primarily at presynaptic terminals in the central nervous system. Alpha synuclein has been associated with several neurodegenerative diseases. A point mutation in the gene coding for the alpha-synuclein protein was the first discovery linking this protein to a rare familial form of Parkinson's disease (PD) . Subsequently, other mutations in the alpha-synuclein gene have been identified in familial PD. The aggregated proteinaceous inclusions called Lewy bodies found in PD and cortical Lewy body dementia (LBD) were discovered to be predominantly alpha-synuclein. Aberrant aggregation of alpha-synuclein has been detected in an increasing number of neurodegenerative diseases, collectively known as synucleopathies. Alpha-synuclein exists physiologically in both soluble and membrane-bound states, in unstructured and alpha-helical conformations, respectively. The physiological function of alpha-synuclein appears to require its translocation between these subcellular compartments and interconversion between the 2 conformations. Abnormal processing of alpha-synuclein is predicted to lead to pathological changes in its binding properties and function.

The Biosensis Oligomeric Alpha Synuclein Rapid enzyme-linked immunosorbent assay (ELISA) Kit is a sandwich ELISA that allows the quantification of Alpha Synuclein Oligomers in less than 4 hours in human serum, plasma (EDTA) and rat brain. This ELISA shows only minimal cross-reactivity with the monomeric form of α-synuclein and beta and gamma synuclein.

Alpha synculein, Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP; SNCA; PARK1

P37840

Human, Rat

The oligomers were made from recombinant human alpha-synuclein, expressed in E. coli

Alpha synuclein oligomers

ELISA

Plasma (EDTA), Serum, Tissue Homogenates

For research use only.

Shipped on ice packs

Store at 2-8°C

The Oligomeric alpha synuclein ELISA shows less than 5% cross reactivity with ⍺-, β- and γ-synuclein proteins.

Colorimetric

Human