Humane GP6-eiwit, hFc-tag

The protein has a predicted molecular mass of 53.1 kDa after removal of the signal peptide. The apparent molecular mass of GP6-hFc is approximately 55-100 kDa due to glycosylation. This gene encodes a platelet membrane glycoprotein of the immunoglobulin superfamily. The encoded protein is a receptor for collagen and plays a critical role in collagen-induced platelet aggregation and thrombus formation. The encoded protein forms a complex with the Fc receptor gamma-chain that initiates the platelet activation signaling cascade upon collagen binding. Mutations in this gene are a cause of platelet-type bleeding disorder-11 (BDPLT11) . Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

BDPLT11; GPIV; GPVI

GP6

The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.

Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing) .Lyophilized proteins are shipped at ambient temperature.