Humane GPR146 volledige lengte eiwit, zijn, vlag Tag (Detergent)

GPR146 (G Protein-Coupled Receptor 146) is a class A orphan G protein-coupled receptor (GPCR) . GPR146 is encoded by the GPR146 gene located on human chromosome 5 (5q12.1) and is broadly expressed in metabolic tissues, including the liver, pancreas, and adipose tissue, suggesting potential roles in energy homeostasis.Emerging evidence links GPR146 to lipid and glucose metabolism. For instance, in vivo studies in rodents indicate that GPR146 knockdown reduces plasma cholesterol and triglyceride levels, implicating it in lipid regulation. Additionally, GPR146 may modulate insulin secretion via interactions with pancreatic β-cells, hinting at relevance in diabetes pathophysiology. (PubMed,31778654, PubMed, 38503280)

GPR146 (G Protein-Coupled Receptor 146) is a class A orphan G protein-coupled receptor (GPCR) . GPR146 is encoded by the GPR146 gene located on human chromosome 5 (5q12.1) and is broadly expressed in metabolic tissues, including the liver, pancreas, and adipose tissue, suggesting potential roles in energy homeostasis.Emerging evidence links GPR146 to lipid and glucose metabolism. For instance, in vivo studies in rodents indicate that GPR146 knockdown reduces plasma cholesterol and triglyceride levels, implicating it in lipid regulation. Additionally, GPR146 may modulate insulin secretion via interactions with pancreatic β-cells, hinting at relevance in diabetes pathophysiology. (PubMed,31778654, PubMed, 38503280)

This protein carries a polyhistidine tag at the N-terminus and a Flag tag at the C-terminus. The protein has a calculated MW of 42.3 kDa.

Trp 2 - Ala 333

GPR146

Unconjugated

N-10xHis & C-Flag

The product MUST be stored at -70°C or lower upon receipt; -70°C for 3 months under sterile conditions.

90%

Liquid

50 mM HEPES, 150 mM NaCl, DDM, CHS, pH7.5

42.3 kDa

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Dry ice

-70°C

500ug*1

E. coli

Human

Q96CH1-1

Glycerol