Humane IL-3 R Beta / CD131 eiwit, zijn tag (MALS geverifieerd)

CD131- the common β Subunit, is a member of the type 1 cytokine receptor family. There are three major classes of heteroreceptor com_x0002_plexes, where the receptor complex utilises a common shared receptor subunit as a signal-transducing chain along with a cytokine specific subunit. These three classes include those which use gp130, those which use γc and those which use the common β subunit, βc (CD131) . CD131 is shared by three of the “four-helical bundle” family of cytokines; IL-3, IL-5 and GM-CSF, and forms a receptor complex along with a cytokine specific α chain for each of these cytokines.Moreover, even though each of these cytokines have their own specific α subunit, the co-utilisation of CD131 suggests a common intra-cellular process of both unique and/or overlapping activities on expressing cells.

CD131- the common β Subunit, is a member of the type 1 cytokine receptor family. There are three major classes of heteroreceptor com_x0002_plexes, where the receptor complex utilises a common shared receptor subunit as a signal-transducing chain along with a cytokine specific subunit. These three classes include those which use gp130, those which use γc and those which use the common β subunit, βc (CD131) . CD131 is shared by three of the “four-helical bundle” family of cytokines; IL-3, IL-5 and GM-CSF, and forms a receptor complex along with a cytokine specific α chain for each of these cytokines.Moreover, even though each of these cytokines have their own specific α subunit, the co-utilisation of CD131 suggests a common intra-cellular process of both unique and/or overlapping activities on expressing cells.

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 50.6 kDa. The protein migrates as 55-65 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Trp 17 - Trp 443

CD131

Unconjugated

C-10xHis

-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.

1.0 EU per μg

95%

Powder

PBS, pH7.4

50.6 kDa

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RT

-20°C

1mg*1

HEK293

Human

P32927-1

Trehalose