Humane NK2R volledige lengte eiwit, vlag, zijn tag (Detergent)

NK2R is a G protein-coupled receptor with high affinity for the tachykinin Substance K (Neurokinin A) . Upon activation, it triggers a phosphatidylinositol-calcium signaling pathway, leading to intracellular calcium release. The receptor's binding affinity follows the order: Substance K > Neuromedin K > Substance P. NK2R also regulates energy metabolism and has shown significant potential in appetite control. Due to its diverse functions, it is considered a promising therapeutic target for conditions such as asthma, irritable bowel syndrome, obesity, and type 2 diabetes.

NK2R is a G protein-coupled receptor with high affinity for the tachykinin Substance K (Neurokinin A) . Upon activation, it triggers a phosphatidylinositol-calcium signaling pathway, leading to intracellular calcium release. The receptor's binding affinity follows the order: Substance K > Neuromedin K > Substance P. NK2R also regulates energy metabolism and has shown significant potential in appetite control. Due to its diverse functions, it is considered a promising therapeutic target for conditions such as asthma, irritable bowel syndrome, obesity, and type 2 diabetes.

This protein carries a flag tag at the N-terminus and a polyhistidine tag at the C-terminus. The protein has a calculated MW of 47.9 kDa. The protein migrates as 53-55 kDa and 65-70 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Gly 2 - Ile 398

NK2R

Unconjugated

N-Flag & C-10xHis

The product MUST be stored at -70°C or lower upon receipt; -70°C for 3 months under sterile conditions.

90%

Liquid

50 mM HEPES, 150 mM NaCl, Buffer B, CHS, pH7.5

47.9 kDa

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Dry ice

-70°C

500ug*1

HEK293

Human

P21452

Glycerol