HVF18-a3-d

HVF18-a3-d is an antimicrobial peptide. HVF18-a3-d reduces NO production. HVF18-a3-d inhibits the production of TNF-α and IL-6, reduces ROS production, and suppresses the TLR4 signaling pathway, as well as LPS-induced phosphorylation of ERK, JNK, and p38 MAPK. HVF18-a3-d exhibits antimicrobial activity against a variety of bacteria by disrupting their outer and inner membranes. HVF18-a3-d protects mice from fatal septic shock induced by Acinetobacter baumannii resistant to Carbapenem. HVF18-a3-d shows anti-inflammatory and antioxidant effects[1].

12352209

Bacterial; ERK; Interleukin Related; JNK; NO Synthase; p38 MAPK; Reactive Oxygen Species (ROS) ; Toll-like Receptor (TLR)

Anti-infection; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; Stem Cell/Wnt

Infection; Inflammation/Immunology

O=C(N[C@H](C(C)C)C(N[C@H](CC1=CC=CC=C1)C(N[C@H](CCCNC(N)=N)C(N[C@H](CC(C)C)C(N[C@H](CCCCN)C(N[C@H](CCCCN)C(N[C@H](CC2=CNC3=CC=CC=C23)C(N[C@H](CC(C)C)C(N[C@H](CCCCN)C(N[C@H](CCCCN)C(N[C@H](C(C)C)C(N[C@H](CC(C)C)C(N[C@H](CCCCN)C(N[C@H](CCCCN)C(N[C@H](CC4=CNC5=CC=CC=C45)C(NCC(N[C@H](CCCCN)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CN

C111H185N31O18

2241.85

[1]Kumar SD, et al. Antibacterial, Antibiofilm, and Anti-inflammatory Effects of a Novel Thrombin-Derived Peptide in Sepsis Models: Insights into Underlying Mechanisms. J Med Chem. 2024 Nov 14;67 (21) :19791-19812.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-P11250/

Peptides

No Development Reported

IL-6; TLR4