Hyaluronanbindingspeptide, biotinegelabeld (TFA)

Hyaluronan-binding peptide, biotin labeled TFA is a biological active peptide. (This peptide is a hyaluronan-binding peptide biotinylated through a C-terminal GGGSK linker. Hyaluronan (HA) is a nonsulfated glycosaminoglycan expressed in the extracellular matrix and on cell surfaces. HA plays a role in fertilization, embryonic development, wound healing, angiogenesis, leukocyte trafficking to inflamed tissues, and cancer metastasis. This peptide has been shown to block HA binding to CD44 receptors and inhibit T cell proliferation.) [1].

12352209

Transmembrane Glycoprotein

Immunology/Inflammation

Cancer; Inflammation/Immunology

97.02

O=C(CCCC[C@@H]1SC[C@]([H])(N2)[C@@]1(NC2=O)[H])NCCCC[C@H](NC([C@@H](NC(CNC(CNC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CN)=O)C)=O)CC3=CNC=N3)=O)CC4=CNC5=CC=CC=C45)=O)CCC(N)=O)=O)CC6=CC=CC=C6)=O)CC(N)=O)=O)C)=O)CC(C)C)=O)[C@@H](C)O)=O)C(C)C)=O)CCCNC(N)=N)=O)=O)=O)=O)CO)=O)C(O)=O.OC(C(F)(F)F)=O.[x]

C89H134N28O24S.xC2HF3O2

2012.25 (free base)

[1]Mummert ME, et al. Development of a peptide inhibitor of hyaluronan-mediated leukocyte trafficking. J Exp Med. 2000 Sep 18;192 (6) :769-79.

Blue Ice

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

http://file.medchemexpress.com/batch_PDF/HY-P5351A/

Peptides

No Development Reported