Hyaluronzuur (natrium) (MW 800kDa)

Hyaluronic acid sodium (MW 800kDa) is a biopolymer composed of repeating units of disaccharides with various applications. Hyaluronic acid sodium is a major component of the extracellular matrix (ECM) . Hyaluronic acid sodium is synthesized at the plasma membrane. Increased hyaluronic acid sodium levels are associated with tumor cell growth, adhesion, migration, invasion and angiogenesis in digestive cancers. Hyaluronic acid sodium participates in tissue remodeling and rapid cell proliferation in some physiological processes including embryonic morphogenesis and wound-healing. Hyaluronic acid sodium activates the PI3K-Akt signaling. Hyaluronic acid sodium acts as a regulator of cancer-associated lymphangiogenesis. Hyaluronic acid sodium also enhances cell invasion and angiogenesis by promoting proteolytic MMP-9 binding to cell surface or stimulating MMP-9 binding to cell surface. Hyaluronic acid sodium can be used as drug delivery for sodium butyrate to improve the anti-proliferative activity on breast cancer cell line. Hyaluronic acid sodium can be studied in joint diseases, wound healing and cancer[1][2][3][4][5].

9067-32-7

12352005

Akt; Bacterial; Endogenous Metabolite; PI3K

Anti-infection; Metabolic Enzyme/Protease; PI3K/Akt/mTOR

COVID-19-immunoregulation

Cancer; Inflammation/Immunology

H2O : 5 mg/mL (ultrasonic)

CCC1[C@@H](O)[C@@H](O)O[C@@H](O[C@H]2[C@H](C(O[Na])=O)OC(OC)[C@@H](O)[C@@H]2O)[C@@H]1NC(C)=O.[n]

[1]Salwowska NM, et al. Physiochemical properties and application of hyaluronic acid: a systematic review. J Cosmet Dermatol. 2016 Dec;15 (4) :520-526. |[2]Wu RL, et al. Hyaluronic acid in digestive cancers. J Cancer Res Clin Oncol. 2017 Jan;143 (1) :1-16. |[3]Kogan G, et al. Hyaluronic acid: a natural biopolymer with a broad range of biomedical and industrial applications. Biotechnol Lett. 2007 Jan;29 (1) :17-25.|[4]Coradini, D., et al., (1999) . Hyaluronic acid as drug delivery for sodium butyrate: improvement of the anti-proliferative activity on a breast-cancer cell line. International journal of cancer, 81 (3), 411-416. |[5]Goa, K. L., & Benfield, P. (1994) . Hyaluronic acid. A review of its pharmacology and use as a surgical aid in ophthalmology, and its therapeutic potential in joint disease and wound healing. Drugs, 47 (3), 536-566.

Blue Ice

-20°C, 3 years (Powder)

http://file.medchemexpress.com/batch_PDF/HY-B0633I/

Biochemical Assay Reagents

No Development Reported