Hydrostatine-TL1

2243975-43-9

Interleukin, ERK, Integrin, JNK, NF-κB, p38 MAPK, TNF

Immunology/Inflammation, Cytoskeletal Signaling, MAPK, NF-κB, Apoptosis

Hydrostatin-TL1 (H-TL1) is a nonapeptide that acts as a TNF-α antagonist. This compound can be isolated from the venom glands of the sea snake Hydrophis cyanocinctus. H-TL1 competitively inhibits the interaction between TNF-α and TNFR1, thus reducing TNF-α cytotoxicity and inflammatory responses. It is applicable for research into TNF-α-related inflammatory diseases such as rheumatoid arthritis, osteoporosis, and inflammatory bowel disease (IBD) .

C([C@@H](NC([C@@H](NC([C@@H](NC([C@H](C)N)=O)[C@@H](C)O)=O)CO)=O)CCCCN)(=O)N1[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CS)=O)CCCCN)=O)CC(C)C)=O)CO)=O)CCC1

C39H71N11O13S

934.11

Ice Packs

-20°C