I-TAC (CXCL11) (Diervrij)

I-TAC is a 'non-ELR' CXC chemokine that is regulated by interferon and signals through the CXCR3 receptor. I-TAC is chemoattractant for IL-2 activated T cells, but does not affect freshly isolated un-stimulated T cells, neutrophils, ormonocytes. Recombinant Human I-TAC (CXCL11) is an 8.3 kDa protein containing 73 amino acid residues, including the four highly conserved cysteine residues present in CXC chemokines.

CXCL11; IP9; H174; IP-9; b-R1; I-TAC; SCYB11; SCYB9B

6373

O14625

NP_005400.1

NM_005409.4

4q21.2

Human

Hamster, Mouse, Rabbit, Human, Monkey

FPMFKRGRCLCIGPGVKAVKVADIEKASIMYPSNNCDKIEVIITLKENKGQRCLNPKSKQARLIIKKVERKNF

< 0.01 ng/µg of protein (< 0.1 EU/µg)

≥ 98% by SDS-PAGE gel and HPLC analyses.

Determined by its ability to chemoattract human T-cells activated with IL-2.

73

Lyophilized

8.3 kDa

E. coli