IA-1 Antilichaam

IA-1 Antibody: IA-1, also known as INSM1, is an essential five zinc-finger transcription factor that while initially identified from an insulinoma cDNA library, is expressed in the developing nervous system. Specifically, IA-1 is expressed as early as E9.5 in mice in the fore-, mid- and hindbrain, spinal cord, retina, and olfactory bulb. It is thought that IA-1 functions as a transcriptional repressor, and is a part of several signaling pathways including those of Notch and sonic hedgehog in addition to that of Ngn3 during pancreatic endocrine cell differentiation. IA-1 is also expressed in multiple tumors, including the majority of neuroendocrine tumors tested so far as well as nearly 100% of all small cell lung carcinomas, indicating that IA-1 may be an important target in cancer therapy.

3642

Q01101

NP_002187

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Cancer

IA-1 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1471 - Rat Thymus Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Bovine: (100%)

IA-1 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

IA-1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

INSM1

Insulinoma-associated 1

Homo sapiens

Lan MS, Li Q, Lu J, et al. Genomic organization, 5'-upstream sequence, and chromosomal localization of an insulinoma-associated intronless gene, IA-1. J. Biol. Chem.1994; 269:14170-4.

Jacob J, Storm R, Castro DS, et al. Insm (IA-1) is an essential component of the regulatory network that specifies monoaminergic neuronal phenotypes in the vertebrate hindbrain. Dev.2009; 136:2477-85.

Breslin MB, Zhu M, and Lan MS. NeuroD1/E47 regulates the E-box element of a novel zinc-finger transcription factor, IA-1, in developing nervous system. J. Biol. Chem.2003; 278:38991-7.

Nelson BR, Hartman BH, Georgi SA, et al. Transient inactivation of Notch signaling synchronizes differentiation of neural progenitor cells. Dev. Biol.2007; 304:479-98.

IA-1 Antibody: IA1, IA-1, IA1, Insulinoma-associated protein 1, Zinc finger protein IA-1

ELISA, WB

4504713

Liquid