IAPP Antibody - N-terminal regio : HRP (ARP41728_P050-HRP)

Islet amyloid polypeptide

DAP, IAP

3375

P10997

NP_000406

Human, Cow, Dog, Horse, Rabbit

The immunogen is a synthetic peptide directed towards the N terminal region of human IAPP

Islet, or insulinoma, amyloid polypeptide is commonly found in pancreatic islets of patients suffering diabetes mellitus type II, or harboring an insulinoma. While the assosciation of amylin with the development of type II diabetes has been known for some time, a direct causative role for amylin has been harder to establish. Studies suggest that amylin, like the related beta-amyloid (Abeta) associated with Alzheimer's disease, can induce apoptotic cell-death in particular cultured cells, an effect that may be relevant to the development of type II diabetes.

COL25A1; RAMP2; RAMP1; PDX1; PCSK2; PCSK1

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Cow: 82%; Dog: 86%; Horse: 93%; Human: 100%; Rabbit: 86%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

4kDa

Wet Ice

89

IAPP

IAPP

Rabbit

Islet amyloid polypeptide

NM_000415

MGILKLQVFLIVLSVALNHLKATPIESHQVEKRKCNTATCATQRLANFLV