IBI-334
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
IBI-334 is a bispecific B7-H3 and EGFR antibody. IBI-334 has an EGFR arm for signal blockage and is coupled with a fine-tuned B7-H3 arm with optimal affinity and binding domain. IBI-334 is afucosylated to enhance its antibody-mediated cell cytotoxicity (ADCC) effects. IBI-334 has a wide range of applications in many EGFR-driven solid tumors[1].
12352203
CD276/B7-H3; EGFR
Immunology/Inflammation; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Cancer-Kinase/protease
Cancer
[IBI-334]
[1]Jian Guan, et al. Abstract LB056: IBI334, a novel ADCC-enhanced B7-H3/EGFR bispecific antibody, demonstrated potent pre-clinical efficacy in solid tumors. Cancer Res (2024) 84 (7_Supplement) : LB056.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-P991092/
Inhibitory Antibodies
Phase 2
Beschrijving
IBI-334 is a bispecific B7-H3 and EGFR antibody. IBI-334 has an EGFR arm for signal blockage and is coupled with a fine-tuned B7-H3 arm with optimal affinity an
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