Ibudilast-d3

Ibudilast-d3 (KC-404-d3) is the deuterium labeled Ibudilast. Ibudilast (KC-404) is a cyclic AMP phosphodiesterase (PDE) inhibitor. Ibudilast has platelet anti-aggregatory effects. Ibudilast can be used for the research of asthma for its inhibitory effects on tracheal smooth muscle contractility. Ibudilast may be a useful neuroprotective and anti-dementia agent counteracting neurotoxicity in activated microglia[1][2].

102064-45-9

12352005

Isotope-Labeled Compounds; Phosphodiesterase (PDE)

Metabolic Enzyme/Protease; Others

COVID-19-immunoregulation

Inflammation/Immunology; Cancer

10 mM in DMSO

C(C(C)C)(=O)C1=C2N(N=C1C(C)C)C(=C(C(=C2[2H])[2H])[2H])[2H]

C14H14D4N2O

233.32

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Mizuno T, et al. Neuroprotective role of phosphodiesterase inhibitor ibudilast on neuronal cell death induced by activated microglia. Neuropharmacology. 2004 Mar;46 (3) :404-11.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-B0763S/

Isotope-Labeled Compounds

No Development Reported