ICRF-193
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
ICRF-193 is a topoisomerase II poison.1 Toposiomerase poisons are a special subclass of topoisomerase inhibitors that stabilize topoisomerase-DNA strand passing intermediates and thus cause the topoisomerases to become a cytotoxic DNA-damaging agent.1 It readily induces DNA strand breaks in V79 and irs-2 Chinese hamster lung fibroblasts via a novel mechanism.2 Displays cardioprotective (against anthracycline toxicity) 3 and anti-inflammatory effects via reduction of IL-1β secretion by macrophages4. An important tool for studying the cellular response to DNA double-strand breaks.5
Unconjugated
Off-white solid
-20°C
Beschrijving
ICRF-193 Beschikbaar in 1 mg. Bestel eenvoudig online met snelle levering.
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