IDE Antilichaam - N-terminalgebied: FITC (ARP30652_P050-FITC)

Insulin-degrading enzyme

INSULYSIN

3416

P14735

NP_004960

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Zebrafish

This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion.

UBC; DCP2; SUMO1; NEDD8; PUS1; TBC1D15; PUS7; ARFIP1; GSPT2; PRMT3; STAT1; SHMT2; SHMT1; PAWR; GSPT1; CTTN; CARS; ATP6V1C1; PEX5; IFIH1; Cdk1; UCHL5; SIRT4; AR; INS; IGF2; IGF1; NR3C1; APP; ZHX2

FITC: Fluorescein Isothiocyanate

Polyclonal Antibody

WB

Affinity Purified

IDE is strongly supported by BioGPS gene expression data to be expressed in HeLa

0.5 mg/ml

Cow: 100%; Dog: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 93%; Pig: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 79%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

118kDa

Wet Ice

1019

IDE

IDE

Rabbit

Insulin-degrading enzyme

NM_004969

LDVHIGSLSDPPNIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSN