Idebenone-13C, d3

Idebenone-13C, d3 is the deuterium labeled and 13C-labeled Idebenone. Idebenone, a well-appreciated mitochondrial protectant, exhibits protective efficacy against neurotoxicity and can be used for the research of Alzheimer's disease, Huntington's disease. Idebenone (oxidised form) has a dose-dependent inhibitory effect on the enzymatic metabolism of arachidonic acid in astroglial homogenates (IC50=16.65 μM). Idebenone, a coenzyme Q10 analog and an antioxidant, induces apoptotic cell death in the human dopaminergic neuroblastoma SHSY-5Y cells[2]. Idebenone quickly crosses the blood-brain barrier.

1189907-75-2

12352211

Apoptosis; Isotope-Labeled Compounds; Mitochondrial Metabolism

Apoptosis; Metabolic Enzyme/Protease; Others

Neuroscience-Neurodegeneration

Neurological Disease

O=C(C(CCCCCCCCCCO)=C(C1=O)C)C(OC)=C1O[13C]([2H])([2H])[2H]

C18 13CH27D3O5

342.45

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W777283/

Isotope-Labeled Compounds

No Development Reported