IDH3G Antilichaam

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD (+) as the electron acceptor and the other NADP (+) . Five isocitrate dehydrogenases have been reported: three NAD (+) -dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP (+) -dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD (+) -dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the gamma subunit of one isozyme of NAD (+) -dependent isocitrate dehydrogenase. This gene is a candidate gene for periventricular heterotopia.

3421

P51553

P51553

Human

This IDH3G antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 366-393 amino acids from the C-terminal region of human IDH3G.

Unconjugated

Primary Antibodies

Obesity, Signal Transduction

This antibody is purified through a protein A column, followed by peptide affinity purification.

Batch dependent

Predicted species reactivity based on immunogen sequence: Bovine, Monkey

Supplied in PBS with 0.09% (W/V) sodium azide.

None

Blue Ice

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

43 kDa

Rabbit Ig

IDH3G

Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial

Homo sapiens

Bzymek, K.P., et al. Biochemistry 46 (18) :5391-5397 (2007)

Soundar, S., et al. J. Biol. Chem. 281 (30) :21073-21081 (2006)

Simpson, J.C., et al. EMBO Rep. 1 (3) :287-292 (2000)

Weiss, C., et al. Biochemistry 39 (7) :1807-1816 (2000)

Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial, Isocitric dehydrogenase subunit gamma, NAD (+) -specific ICDH subunit gamma, IDH3G

WB, Flow

1708404

Liquid